ニュース

2016年12月19日 掲載 (Published 12/19/2016)


「Biophysics and Physicobiology」にKeitaro Shibata et al. “Actin binding domain of filamin distinguishes posterior from anterior actin filaments in migrating Dictyostelium cells”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Keitaro Shibata, Akira Nagasaki, Hiroyuki Adachi, Taro Q. P. Uyeda “Actin binding domain of filamin distinguishes posterior from anterior actin filaments in migrating Dictyostelium cells”  

【Significance】
Actin binding domain of filamin can distinguish different actin filaments in polarized cells

It is not well understood how different actin filaments interact with different actin binding proteins (ABPs) in a spatially regulated manner. Here, we demonstrate that the actin binding domain of filamin (ABDFLN) in the middle of elongated, polarized Dictyostelium cells rapidly and specifically binds to posterior actin filaments. The speed of translocation was much faster than the retrograde flow of actin cortex, suggesting that ABDFLN diffusing in the cytoplasm was captured by posterior actin filaments. We suggest that this specific interaction depends on structural polymorphism of actin filaments, and a similar mechanism may contribute to intracellular localization of other ABPs.


Biophysics and Physicobiology, Vol.13, pp. 321-331

URL:https://www.jstage.jst.go.jp/article/biophysico/13/0/13_321/_article