2017年02月27日 掲載 (Published 02/27/2017)
日本生物物理学会欧文誌［Biophysics and Physicobiology］に以下の論文が新規掲載されました。
Yohei Murakami, Masanori Koyama, Shigeyuki Oba, Shinya Kuroda and Shin Ishii “Model-based control of the temporal patterns of intracellular signaling in silico”
Model-based control of the temporal patterns of intracellular signaling in silico
Amongst many dynamical properties of the intracellular signal transduction system, the one that holds particular importance is the relationship between the dynamics of upstream molecules and the dynamics of downstream molecules. A useful tool in understanding this relationship is the methodology to control the dynamics of intracellular molecules with an extracellular stimulus. In this article, we present a model-based control method that dynamically changes the concentration of a controllable upstream molecule to make the target downstream molecule trace a desired time course.
Biophysics and Physicobiology, Vol.14, pp. 29-40