ニュース

2017年06月07日 掲載 (Published 06/07/2017)


「Biophysics and Physicobiology」にRyo Yoshizawa et al. “Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Ryo Yoshizawa, Nobuhisa Umeki, Masataka Yanagawa, Masayuki Murata and Yasushi Sako “Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral”

【Significance】
Single-molecule fluorescence analysis of Ras-RalGDS-Ral pathway

Despite the importance of the signal transduction from Ras to Ral in tumorigenesis and inflammation, the mechanism is not fully understood. Several reports have demonstrated that RalGDS translocates from the cytoplasm to the plasma membrane to receive the Ras signal and transduces it to effectors, including Ral. However, it is difficult to measure the kinetics and dynamics of protein interactions in living cells with conventional methods. Single-molecule fluorescence imaging is a powerful tool with which to clarify the mechanisms of protein reactions. We used this technique to determine the mechanism of the Ras–Ral signaling mediated by RalGDS.

Biophysics and Physicobiology, Vol.14, pp. 75-84

URL:https://www.jstage.jst.go.jp/article/biophysico/14/0/14_75/_article