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「Biophysics and Physicobiology」にHiroshi Hashimoto et al. “Structural basis for the molecular interactions in DNA damage tolerances”を掲載

2017年12月22日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Hiroshi Hashimoto, Asami Hishiki, Kodai Hara and Sotaro Kikuchi “Structural basis for the molecular interactions in DNA damage tolerances”

【Significance】
Molecular mechanisms underlying interactions to avoid replication arrest by DNA damage

DNA damage tolerance (DDT) is crucial for cell survival and genome stability, although it is not a repair pathway. Paradoxically, DDT is associated with cancer development and thus the molecular interactions involved in DDT could be expected to be a drug target for cancer therapy. Crystal structures of protein-protein and protein-DNA complexes in DDT might provide the structural basis for novel strategy in drug discovery.


Biophysics and Physicobiology, Vol.14, pp. 199-205URL:https://www.jstage.jst.go.jp/article/biophysico/14/0/14_199/_article


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