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「Biophysics and Physicobiology」にRyuma Sato et al. “The binding structure and affinity of photodamaged duplex DNA with members of the otolyase/cryptochrome family: A computational study”を掲載

2018年01月22日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Ryuma Sato, Ryuhei Harada and Yasuteru Shigeta
“The binding structure and affinity of photodamaged duplex DNA with members of the photolyase/cryptochrome family: A computational study”

【Significance】
The binding affinity of photodamaged duplex DNA

If the UV-induced DNA damages are not repaired, they inflict enormous damage on life. The photolyases have the DNA repair function and the existence of that has been identified in the species from bacteria to plant. The homolog of photolyases, cryptochrome-DASH, has been identified in human. However, cryptochrome-DASH did not indicate the repair quantum yield of equality to photolyases. To clarify that reason, we investigated the duplex DNA binding affinity for photolyases and cryptochrome-DASH by using molecular dynamics simulation and molecular mechanics/Poisson-Boltzmann surface area method. We indicated that the contribution of the protein surface to duplex DNA binding was important.


Biophysics and Physicobiology, Vol.15, pp. 18-27URL:https://www.jstage.jst.go.jp/article/biophysico/15/0/15_18/_article


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