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「Biophysics and Physicobiology」にMika Sakamoto et al. “Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins”を掲載

2019年02月15日 学会から


日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Mika Sakamoto, Hirofumi Suzuki, Kei Yura “Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins”

【Significance】
Disease related variation sites on ABC transporters

ABC transporter is known to be involved in multidrug transport and its function relates to drug resistance. Nucleotide variations in ABC transporter genes found in human genomes may relate to different responses to drugs, but only a few studies have been conducted on the relationship between the atomic function of the protein and the variations. We took a database-driven approach to address this relationship and found that variations at pivot-like, ATP-binding and membrane-surface regions tend to be annotated as pathogenic variation in the databases.


Biophysics and Physicobiology, Vol.16, pp. 68-79
URL: https://doi.org/10.2142/biophysico.16.0_68


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