(Takashi Tominaga, Riichi Kajiwara, Yoko Tominaga, Biophysics and Physicobiology 20, e200015 (2023), DOI: 10.2142/biophysico.bppb-v20.0015)
Understanding neural plasticity, a fundamental mechanism of the brain, is critical to unraveling the complexity of circuits. Conventional methods have limited our ability to capture dynamic changes in neural circuit activity. In our review, "Stable wide-field voltage imaging for observing neuronal plasticity at the neuronal network level," we present a solution. Using a real-time voltage-sensitive dye (VSD) imaging method, we demonstrate its efficacy in capturing plastic changes within the hippocampal circuit. The cover image shows the magnitude of VSD signal changes corresponding to induced long-term potentiation (LTP) in a visual representation of the hippocampal slice illuminated with green excitation light.