「Biophysics and Physicobiology」にNaoki Arai et al. “Analysis of an ATP-induced conformational transition of ABC transporter MsbA using a coarse-grained model ”を掲載
2017 December 07 BPPB
日本生物物理学会欧文誌［Biophysics and Physicobiology］に以下の論文が新規掲載されました。
Naoki Arai, Tadaomi Furuta and Minoru Sakurai “Analysis of an ATP-induced conformational transition of ABC transporter MsbA using a coarse-grained model”
【Significance】
Role of ATP binding
Upon the binding of ATP to nucleotide binding domains (NBDs), ATP-binding cassette (ABC) exporters undergo a conformational transition from an inward-facing (IF) to an outward-facing (OF) state. This is a typical example of chemo-mechanical coupling. Here, the IF→OF transition of an ABC exporter, MsbA, was studied by solving the equation of motion under an elastic network model, where ATP was represented as a single node. It was found that 1) the twisting motion of the NBDs is indispensable for causing the opening of transmembrane domains, 2) ATP binding energy is converted into distortion energy of several transmembrane helices.
Biophysics and Physicobiology, Vol.14, pp. 161-171
URL:https://www.jstage.jst.go.jp/article/biophysico/14/0/14_161/_article
