An article with the title "Diverse reactions catalyzed by cytochrome P450 and biosynthesis of steroid hormone" by Keisuke Fujiyama, Tomoya Hino, Shingo Nagano is published.
2022 June 21 BPPB
A following article is published in "Biophysics and Physicobiology".
Keisuke Fujiyama, Tomoya Hino, Shingo Nagano
"Diverse reactions catalyzed by cytochrome P450 and biosynthesis of steroid hormone"
【Significance】
Steroid hormones regulate the physiologies of animals, plants, and insects, and most steroid hormone biosynthetic pathways, excluding those in insects have been clarified. Numerous cytochrome P450s (CYPs) are involved in animal steroid hormone biosynthesis, and their structures and reaction mechanisms have been extensively studied. However, those of plants and insects are yet to be fully investigated. Recently, we determined CYP90B1 structures, a key enzyme in brassinosteroid (BR) biosynthesis, and clarified the stereo-selective hydroxylation mechanism. Therefore, this review summarizes the current research progress on the P450 structure and its reaction mechanism in animal and plant steroid biosynthesis.
Biophysics Physicobiology, 2022, Volume 19, Article ID: e190021
URL:https://doi.org/10.2142/biophysico.bppb-v19.0021
