ニュース

2015年03月02日 掲載 (Published 03/02/2015)


「BIOPHYSICS」にKeigo Ikezaki et al."Lever arm extension of myosin VI is unnecessary for the adjacent binding state"を掲載

日本生物物理学会欧文誌[BIOPHYSICS]に以下の論文が新規掲載されました。

Keigo Ikezaki, Tomotaka Komori, Yoshiyuki Arai, Toshio Yanagida
”Lever arm extension of myosin VI is unnecessary for the adjacent binding state”

【Significance】
How myosin VI achieves its unique binding state

Myosin VI is a processive myosin that has a unique stepping including three kinds of steps: large, small and backward steps. Recently, we proposed the parallel lever arms model to explain the adjacent binding state, which is necessary for this unique stepping. However, the adjacent binding state could be also explained by folding a lever arm extension (LAE) of myosin VI. To tackle this issue, we constructed a myosin chimera that replaces the LAE with a rigid lever arm and investigated its steps. Our result indicates that myosin VI takes its unique stepping according to the parallel lever arm model.

BIOPHYSICS, Vol.11, pp. 47-53

URL:https://www.jstage.jst.go.jp/article/biophysics/11/0/11_47/_article