ニュース

2015年04月20日 掲載 (Published 04/20/2015)


「BIOPHYSICS」に Saeko Yanaka et al." Revealing the peptide presenting process of human leukocyte antigen through the analysis of fluctuation"を掲載

日本生物物理学会欧文誌[BIOPHYSICS]に以下の論文が新規掲載されました。

Saeko Yanaka, Takamasa Ueno, Kouhei Tsumoto, Kenji Sugase
”Revealing the peptide presenting process of human leukocyte antigen through the analysis of fluctuation”

【Significance】
Fluctuation regulates the peptide presentation of human leukocyte antigen

Structural fluctuation on microsecond time scale has been reported to play an important role in proteins that undergo significant structural changes during their expression of function. However, protein motions could contribute to the function of proteins, even if no significant structural difference is observed in crystal structures of different states of their function. In this review we introduce our recent reports on the stabilization mechanism of human leukocyte antigen (HLA), where the fluctuation of HLA contributes to its function without obvious changes in the crystal structure. We discuss the possibility of fluctuation contributing to several biophysical properties of HLA.


BIOPHYSICS, Vol.11, pp. 103-106

URL:http://doi.org/10.2142/biophysics.11.103