ニュース

2015年11月13日 掲載 (Published 11/13/2015)


「Biophysics and Physicobiology」に Mika Morikawa et al. “Subattomole detection of adiponectin in urine by ultrasensitive ELISA coupled with thio-NAD cycling”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Mika Morikawa, Rina Naito, Koichi Mita, Satoshi Watabe, Kazunari Nakaishi, Teruki Yoshimura, Toshiaki Miura, Seiichi Hashida and Etsuro Ito
“Subattomole detection of adiponectin in urine by ultrasensitive ELISA coupled with thio-NAD cycling”

【Significance】
Noninvasive monitoring of trace amounts of proteins in urine

In the last year, we developed a de novo, ultrasensitive ELISA coupled with thio-NAD cycling to detect trace amounts of proteins (BIOPHYSICS, 10, 49-54). In the present study, we have succeeded in detecting proteins (adiponectin) in urine, but not in blood, at the subattomole level. Thus, our ultrasensitive ELISA, which does not employ special tools or chemicals such as radioisotopes or fluorescent probes, paves the way toward simple, fast and noninvasive measurements for a variety of diseases.

Biophysics and Physicobiology, Vol.12, pp. 79-86

URL:http://doi.org/10.2142/biophysico.12.0_79