ニュース

2015年12月28日 掲載 (Published 12/28/2015)


「Biophysics and Physicobiology」に Tatsuhito Matsuo et al. “Structures of the troponin core domain containing the cardiomyopathy-causing mutants studied by small-angle X-ray scattering”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Tatsuhito Matsuo, Soichi Takeda, Toshiro and Satoru Fujiwara 
“Structures of the troponin core domain containing the cardiomyopathy-causing mutants studied by small-angle X-ray scattering”

【Significance】
A small-angle x-ray scattering study of the disease-related mutants of human cardiac troponin

Troponin (Tn), which consists of three subunits (TnC, TnI, TnT), regulates muscle contraction via the interaction of TnT with tropomyosin (Tm). Various mutations within Tn molecules are known to cause familial cardiomyopathy. In this study, we have detected the difference in the solution structures of wild-type human cardiac Tn and cardiomyopathy-causing mutants (K247R and E244D mutations of TnT) by small-angle x-ray scattering combined with model calculations: The N- and C- terminal regions of TnT become closer to the central region of the whole molecule by the mutations, suggesting that the mutations affect the interaction between TnT and Tm.


Biophysics and Physicobiology, Vol.12, pp. 145-158

URL:http://doi.org/10.2142/biophysico.12.0_145