ニュース

2016年01月20日 掲載 (Published 01/20/2016)


「Biophysics and Physicobiology」に Yuki Nakamura et al. “Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Yuki Nakamura, Kayo Hibino, Toshio Yanagida and Yasushi Sako   
“Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains”

【Significance】
SOS/RAS positive feedback is regulated by multiple interactions between SOS and membrane components

RAS is one of the hub proteins which governs integration and divergence of various signal transduction pathways in animal cells. Activity of RAS is regulated by a positive feedback loop consisting of RAS and its activator SOS. However, the mechanism and function of the feedback loop are not fully understood especially in living cells. Here, we show that this feedback system is regulated to switch on after simultaneous interactions between SOS domains and plasma membrane components. The positive feedback is indispensable for RAS to transduce signals to the downstream RAF molecule.


Biophysics and Physicobiology, Vol.13, pp.1-11

URL:http://doi.org/10.2142/biophysico.13.0_1