ニュース

2016年07月15日 掲載 (Published 07/15/2016)


「Biophysics and Physicobiology」に 〈Special Issue: "Protein-Ligand Interactions"〉 Tsukasa Nakamura et al. “Effects of the difference in similarity measures on the comparison of ligand-binding pockets using a reduced vector representation of pockets”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Tsukasa Nakamura, Kentaro Tomii
“Effects of the difference in similarity measures on the comparison of ligand-binding pockets using a reduced vector representation of pockets”

【Significance】
Different similarity measures effects on protein ligand-binding pocket comparison using a vector representation of pockets

As the recent increase of protein structure information, comprehensive analysis of protein ligand-binding pockets demands an efficient method for comparing them. Based on our previous method using a vector representation of pockets, we conducted this study to expand and revise similarity measures of pockets by both changing the definition and increasing the number of pocket descriptors, and by using the PAM50 matrix. We investigated the effects of those modifications with two datasets, and found that the new method exhibits slightly higher detection performance of similar pockets than the previous method and an existing accurate alignment-dependent method.


Biophysics and Physicobiology, Vol.13, pp. 139-147

URL:https://www.jstage.jst.go.jp/article/biophysico/13/0/13_139/_article