ニュース

2016年07月15日 掲載 (Published 07/15/2016)


「Biophysics and Physicobiology」に 〈Special Issue: "Protein-Ligand Interactions"〉 Oanh T.P. Kim et al. “In silico studies for the interaction of tumor necrosis factor-alpha (TNF-α) with different saponins from Vietnamese ginseng (Panax vietnamesis)”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Oanh T. P. Kim, Manh D. Le, Hoang X. Trinh, Hai V. Nong
In silico studies for the interaction of tumor necrosis factor-alpha (TNF-α) with different saponins from Vietnamese ginseng (Panax vietnamesis)”

【Significance】
Potential TNF-α inhibitors from Vietnamese ginseng

Among ginseng saponins, the ocotillol-type ginsenoside, especially majonoside-R2, from Vietnamese ginseng (Panax vietnamesis), had been found to have highest inhibitory effect on tumor necrosis factor-alpha (TNF-α). Our study predicted the binding modes of three different triterpene saponins (majonoside-R2, vina-ginsenoside R1 and vina-ginsenoside R2) to TNF-α, which will be helpful for further investigation of the inhibitory mechanism. The information at molecular level is very important for understanding the clinical advantages of the triterpene saponins.


Biophysics and Physicobiology, Vol.13, pp. 173-180

URL:https://www.jstage.jst.go.jp/article/biophysico/13/0/13_173/_article