ニュース

2017年02月01日 掲載 (Published 02/01/2017)


「Biophysics and Physicobiology」に Alemeh Zamani et al. “Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Alemeh Zamani, Shigeo Sakuragi, Toru Ishizuka, Hiromu Yawo“Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization”

【Significance】
Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization

Channelrhodopsins are desensitized during long irradiation of light. Zamani et al . provided evidences that the desensitized photocycle is kinetically distinct and both rates from basal to conductive and conductive to basal states are decelerated during desensitization. Using channelrhodopsin-1/2 chimeras, they revealed that the transmembrane helices, TM1 and TM2, were the determinants of both basal-to-conductive and conductive-to-basal transitions whereas TM4 may contribute the basal-to-conductive and TM5 may contribute the conductive-to-basal transitions, respectively. The TM1 and 2 are the main structures involved in two features of desensitization, the stabilization of protein conformation and the charge distribution around the retinal-Schiff base (RSB).


Biophysics and Physicobiology, Vol.14, pp. 13-22

URL:https://www.jstage.jst.go.jp/article/biophysico/14/0/14_13/_article