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「Biophysics and Physicobiology」にYumeka Yamauchi et al. “Molecular properties of a DTD channelrhodopsin from Guillardia theta ”を掲載

2017年05月24日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Yumeka Yamauchi, Masae Konno, Shota Ito, Satoshi P. Tsunoda, Keiichi Inoue and Hideki Kandori “Molecular properties of a DTD channelrhodopsin from Guillardia theta

【Significance】
Molecular properties of a DTD channelrhodopsin from Guillardia theta

Functions of microbial rhodopsins are characterized by the motif in C-helix. The DTD motif is unique to an archaeal light-driven proton pump such as bacteriorhodopsin. Here we report that a DTD rhodopsin from G. theta (GtCCR4) functions as a light-gated cation channel, which also pumps protons outwardly. The primary reaction is a photoisomerization from an all- trans form to a 13-cis form of retinal, like other microbial rhodopsins, but protein structural changes are much smaller in GtCCR4 than in channelrhodopsin 2 from Chlamydomonas reinhardtii. The structural dynamics of retinal and channels are tightly coupled in the late intermediates, which are unique to GtCCR4.


Biophysics and Physicobiology, Vol.14, pp. 57-66
URL: https://www.jstage.jst.go.jp/article/biophysico/14/0/14_57/_article



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