ニュース

「Biophysics and Physicobiology」にKenichi Kouyama et al. “Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1”を掲載

2019年02月08日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Kenichi Kouyama, Kouta Mayanagi, Setsu Nakae, Yoshisuke Nishi, Masanao Miwa, Tsuyoshi Shirai “Single-particle analysis of full-length human poly(ADP-ribose) polymerase 1”

【Significance】
h-PARP1 single-particle analysis

Poly(ADP-ribose) polymerase 1 (PARP1) is the first line sensor of DNA damages in the cell, for which the active quaternary structure is still under debates. Although PARP1 has been thought to form a dimer on damaged DNA for trans-PolyADP-ribosylation, several recent studies detected a monomeric DNA recognition and cis-PolyADP-ribosylation of PARP1. The present study provides the first structural evidence of dimeric conformation of full-length human PARP1 with single-particle electron microscopy.


Biophysics and Physicobiology, Vol.16, pp. 59-67
URL: https://doi.org/10.2142/biophysico.16.0_59


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