ニュース

「Biophysics and Physicobiology」にKatsuhide Yutani et al. “Confirmation of the formation of salt bridges in the denatured state of CutA1 protein using molecular dynamics simulations”を掲載

2019年11月29日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Katsuhide Yutani, Yoshinori Matsuura, Yasumasa Joti “Confirmation of the formation of salt bridges in the denatured state of CutA1 protein using molecular dynamics simulations”

【Significance】
Charged residues in proteins contribute to conformational stabilities via entropic effects in the denatured state

It remains unclear how the abundant charged residues in proteins from hyperthermophiles contribute to the stabilization of proteins. Previously, based on MD simulations, we proposed that the charged residues contribute to their conformational stabilities via entropic effects due to the formation of salt bridges in the denatured state, which equilibrates with the native state under physiological conditions. Because the quality of MD results is strongly dependent on the force fields used, in this study we performed the MD simulations using a different force field at more severe conditions. Obtained results corroborated our previous proposal.

Biophysics and Physicobiology, Vol.16, 176-184
URL:https://doi.org/10.2142/biophysico.16.0_176


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