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「Biophysics and Physicobiology」にHiroshi Wako et al. “Dynamic properties of oligomers that characterize low-frequency normal modes”を掲載

2019年11月29日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Hiroshi Wako, Shigeru Endo “Dynamic properties of oligomers that characterize low-frequency normal modes”

【Significance】
Dynamic properties of oligomers that characterize low-frequency normal modes

Dynamics of oligomeric proteins were studied by elastic network model-based normal mode analysis to characterize their large-scale concerted motions. (1) The rigid-body motions of individual subunits were characterized by the radial, tangential, and axial components in a cylindrical coordinate system. (2) The motions of atoms on the inter-subunit interfaces were characterized by the opposing motions of intra-subunit deformation and rigid-body motion of the subunit. (3) A dynamic protein structure network was defined in each mode, and the centrality measure, betweenness, was calculated for each residue. The results indicate that the residues with high betweenness play an important role in oligomer dynamics.

Biophysics and Physicobiology, Vol.16, 220-231
URL:https://doi.org/10.2142/biophysico.16.0_220


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