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「Biophysics and Physicobiology」にRuth Veevers et al. “Methodological improvements for the analysis of domain movements in large biomolecular complexes”を掲載

2019年11月29日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Ruth Veevers, Steven Hayward “Methodological improvements for the analysis of domain movements in large biomolecular complexes”

【Significance】
Methodological improvements for the analysis of domain movements in large biomolecular complexes

Biomolecules exhibit complex shape changing movements during function that are difficult to interpret at the atomic level of detail. The DynDom methodology attempts to describe conformational change in terms of relative movements of domains as quasi-rigid bodies. Here we extend the DynDom methodology by incorporating all six degrees of freedom that describe rigid body movements into the domain identification process. The new tool, DynDom6D, also determines interdomain bending regions. DynDom6D is a platform-independent implementation which can analyse biomolecules comprising protein, DNA and RNA, and employs an alignment method to automatically achieve the required equivalence of atoms in the two structures.

Biophysics and Physicobiology, Vol.16, 328-336
URL:https://doi.org/10.2142/biophysico.16.0_328


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