ニュース

「Biophysics and Physicobiology」にHidetoshi Kono et al. “Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome”を掲載

2019年11月29日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Hidetoshi Kono, Shun Sakuraba, Hisashi Ishida “Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome”

【Significance】
Unwrapping outer superhelical turn of CENP-A nucleosome

Because histone proteins have their variants and are subject to posttranslational modification, there are a variety of
constitutions for nucleosomes which are the fundamental structural unit of chromatin. To investigate differences between the canonical H3 nucleosome and a H3 variant, CENP-A nucleosome, free energy profile for DNA unwrapping of CENP-A nucleosome was calculated. The profile shows that 16 to 22 bp unwrapped states are the most stable for CENP-A nucleosome, indicating that the CENP-A nucleosome is poised to provide scaffolds for kinetochore proteins.

Biophysics and Physicobiology, Vol.16, 337-343
URL:https://doi.org/10.2142/biophysico.16.0_337


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