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「Biophysics and Physicobiology」にYujiro Nagasaka et al. “Gate-keeper of ion transport ―a highly conserved helix-3 tryptophan in a channelrhodopsin chimera, C1C2/ChRWR”を掲載

2020年06月10日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が早期公開されました。

Yujiro Nagasaka, Shoko Hososhima, Naoko Kubo, Takashi Nagata, Hideki Kandori, Keiichi Inoue and Hiromu Yawo “Gate-keeper of ion transport ―a highly conserved helix-3 tryptophan in a channelrhodopsin chimera, C1C2/ChRWR”

【Significance】
Channelrhodopsin gate keeper ―a highly conserved helix-3 tryptophan among microbial rhodopsins

Since the first report of bacteriorhodopsin in 1971, the family of microbial rhodopsins with various light-driven functions has been expanding. The tryptophan homologous to Trp 86 of bacteriorhodopsin is highly conserved among microbial rhodopsins and forms a retinal binding pocket with other amino acids. However, the precise role of this tryptophan in the ion transport function has remained unknown for over 40 years. Nagasaka et al. revealed for the first time that this tryptophan has a role of “gate keeper” of ion transport in a channelrhodopsin. That is, it regulates the structure involved in the gating-on and -off of the cation channel.

URL: https://doi.org/10.2142/biophysico.BSJ-2020007


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