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「Biophysics and Physicobiology」に Masayuki Oda による "Structural basis for Ca2+-dependent catalysis of a cutinase-like enzyme and its engineering: application to enzymatic PET depolymerization" を掲載

2021年07月28日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Masayuki Oda
"Structural basis for Ca2+-dependent catalysis of a cutinase-like enzyme and its engineering: application to enzymatic PET depolymerization"

【Significance】
Enzymatic depolymerization of polyethylene terephthalate (PET) followed by recycling is an attractive method for solving severe environmental problems worldwide. A cutinase-like enzyme, Cut190, is one such candidate enzymes, and engineered Cut190 mutants could catalyze substrates around the PET glass transition temperature. Crystal structure analysis of the Cut190 mutants in the absence or presence of Ca2+ and substrates revealed the presence of “open, closed, engaged, and ejecting” forms, which correspond to the respective conformations in the stages of catalysis. This review focuses on the Ca2+-regulated structure-activity relationship of Cut190 and its applications.

Biophysics Physicobiology, 2021, Volume 18, Pages 168-176



URL:https://doi.org/10.2142/biophysico.bppb-v18.018


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