ニュース

2015年03月11日 掲載 (Published 03/11/2015)


「BIOPHYSICS」にVarvara Dyakonova et al."The activity of isolated snail neurons controlling locomotion is affected by glucose"を掲載

日本生物物理学会欧文誌[BIOPHYSICS]に以下の論文が新規掲載されました。

Varvara Dyakonova, László Hernádi, Etsuro Ito, Taisia Dyakonova, Igor Zakharov, Dmitri Sakharov
”The activity of isolated snail neurons controlling locomotion is affected by glucose”

【Significance】
Glucose affects the activity of locomotor neurons

How do neurons know about changes in the overall state of the organism? In the pond snail Lymnaea stagnalis, neurons that control locomotion increase their activity when animals are hungry and decrease it after satiation. However, the mechanisms by which hunger signals to these cells remain unknown. We demonstrate here that locomotor neurons can directly sense the concentration of glucose, a metabolic indicator of nutritional state. Moreover, glucose changes the chemical microenvironment of the neurons exerting additional indirect effects. These results are in accordance with the hypothesis that extracellular content of signals and metabolic molecules reflects the behavioral state.



BIOPHYSICS, Vol.11, pp. 55-60

URL:https://www.jstage.jst.go.jp/article/biophysics/11/0/11_55/_article