ニュース

2016年07月15日 掲載 (Published 07/15/2016)


「Biophysics and Physicobiology」に 〈Special Issue: "Protein-Ligand Interactions"〉 Georgios Iakovou et al. “Determination of locked interfaces in biomolecular complexes using Haptimol_RD”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Georgios Iakovou, Stephen Laycock, Steven Hayward
“Determination of locked interfaces in biomolecular complexes using Haptimol_RD”

【Significance】
Determination of locked interfaces in biomolecular complexes using Haptimol_RD

Recently we have developed a software tool, Haptimol_RD, which allows the user to control a ligand molecule via a haptic device and feel its interactions with a receptor molecule. Here we have used Haptimol_RD on two types of dimers, those with an interwinding subunit interface and those without a non-interwinding subunit interface. The results show that for the interwinding dimers one or both the subunits much change conformation upon complex formation whereas for the non-interwinding dimers this is not necessary. This leads to a new concept relating to steric interactions between subunits; that of a “locked” interface.


Biophysics and Physicobiology, Vol.13, pp. 97-103

URL:https://www.jstage.jst.go.jp/article/biophysico/13/0/13_97/_article