ニュース

2018年01月12日 掲載 (Published 01/12/2018)


「Biophysics and Physicobiology」にDaisuke Miyashiro et al. “Radial stiffness characteristics of the overlap regions of sarcomeres in isolated skeletal myofibrils in pre-force generating state”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Daisuke Miyashiro, Misato Ohtsuki, Yuta Shimamoto, Jun’ichi Wakayama, Yuki Kunioka,Takakazu Kobayashi, Shin’ichi Ishiwata and Takenori Yamada “Radial stiffness characteristics of the overlap regions of sarcomeres in isolated skeletal myofibrils in pre-force generating state”

【Significance】
Radial stiffness of actomyosin filament lattice

The measurements of radial stiffness with AFM of an overlap region in sarcomeres of skeletal myofibrils showed that the cross-bridges in pre-force generating state realized by the addition of BDM (relaxing reagent) are anisotropically and visco-elastically attached to the thin filaments. The radial stiffness in force-generating state with BDM was comparable to that without BDM, whereas the axial stiffness of contracting fibers was substantially reduced with BDM.


Biophysics and Physicobiology, Vol.14, pp. 207–220

URL:https://www.jstage.jst.go.jp/article/biophysico/14/0/14_207/_article