2021年12月04日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。
Katsumasa Irie
"The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels"
【Significance】
Prokaryotic proteins play an important role in the structural biology. Voltage-dependent Ca2+ channels (Cavs) are indispensable for coupling action potentials with Ca2+ signaling. Cavs were also predicted to have a prokaryotic counterpart; however, it has not been identified, yet. The homotetrameric channel obtained from Meiothermus ruber generates the calcium ion specific current. This channel belongs to a different cluster of phylogenetic trees than canonical prokaryotic channels. The glycine residue of its selectivity filter is a determinant for Ca2+ selectivity. This glycine residue is well conserved among eukaryotic Cavs, suggesting that there is a universal mechanism for Ca2+ selectivity.
Biophysics Physicobiology, 2021, Volume 18, Pages 274-283
URL: https://doi.org/10.2142/biophysico.bppb-v18.033