2022年05月11日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。
Keisuke Inoue, Shoji Takada, Tsuyoshi Terakawa
"Coarse-grained molecular dynamics simulations of base-pair mismatch recognition protein MutS sliding along DNA"
【Significance】
The mismatch recognition protein MutS should search a DNA base-pair mismatch from millions of base-pairs. Previous studies suggested that the protein slides along DNA in rotation-coupled and uncoupled manners depending on bound nucleotide states. However, detailed structural dynamics of bacterial MutS during sliding remains unclear. Our coarse-grained molecular dynamics simulations elucidated that MutS slides along DNA grooves with different frequency of groove-crossing events depending on the nucleotide state. The simulations revealed structural dynamics details of bacterial MutS sliding along DNA in unprecedented resolution.
Biophysics Physicobiology, 2022, Volume 19, Article ID: e190015
URL: https://doi.org/10.2142/biophysico.bppb-v19.0015