2019年11月29日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。
Kei Moritsugu, Tsubasa Ito, Akinori Kidera “Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP3 receptor”
【Significance】
Allosteric structural change of IP3 receptor
Allostery has long been a key concept of biomolecular physics in the context of molecular function. Here, we simulated the allosteric structural change of IBC/SD domains in IP3R and found the response upon IP3 binding appearing in two different modes: one with a collective motion within a linear response regime and the other with an overamplified motion beyond the linear regime. The domain and subunit arrangement in IP3R is designed to maintain collective and linear dynamics, which enables the large-scale allosteric communication from the IP3 binding site to the ion channel gate in IP3R.
Biophysics and Physicobiology, Vol.16, 232-239
URL: https://doi.org/10.2142/biophysico.16.0_232