Biophysics and Physicobiology Editors' Choice Award

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Biophysics and Physicobiology Editors' Choice Award

日本生物物理学会では、前年にBiophysics and Physicobiology誌に掲載された論文(依頼論文は原則対象外)の中から、編集委員会による選考を経て、生物物理学に寄与するユニークな論文に対して、「Biophysics and Physicobiology Editors' Choice Award」を授与します。



Biophysics and Physicobiology Editors' Choice Award選考規定

第7回Biophysics and Physicobiology Editors' Choice Award受賞論文(2020)

“Uncovering dehydration in cytochrome c refolding from urea- and guanidine hydrochloride-denatured unfolded state by high pressure spectroscopy”
Shohei Konno, Kentaro Doi, Koichiro Ishimori
Biophysics and Physicobiology, Vol. 16, pp. 18-27 (2019)


 How does proteins unfold under water molecules in environment? One problem related to estimating the hydrophobic effect on protein folding is the lack of understanding regarding the evaluation of the hydration effect. These authors revealed by using high pressure absorption spectroscopy and mutation of a neighboring amino residue near heme in Cyt c.

“Functional significance of HCM mutants of tropomyosin, V95A and D175N, studied with in vitro motility assays”
Shuya Ishii, Madoka Suzuki, Shin’ichi Ishiwata, Masataka Kawai
Biophysics and Physicobiology, Vol. 16, pp. 28-40(2019)


 The majority of hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere proteins. The authors focused tropomyosin (Tpm)’s HCM mutants in humans, V95A and D175N, and revealed the difference between the wild type and the mutants with in vitro motility assay using optical tweezers at the single molecular level. The sliding velocity during relaxation was significantly increased in these mutants compared to wild type (WT) tropomyosin. Ca2+-activatable sliding force decreased in V95A and increased in D175N. The duty ratio determined at the steady state of force generation at saturating [Ca2+] decreased in V95A and increased in D175N. They concluded that HCM mutants of tropomyosin differently modulate molecular processes of the actomyosin interaction. These results suggested that the in vitro motility assay was able to distinguish the property of HCM mutants of Tpm based on sliding force and velocity. From the research of hypertrophic cardiomyopathy, the Editor-in-Charge recommends for the award.

“Second harmonic generation polarization microscopy as a tool for protein structure analysis ”
Junichi Kaneshiro, Yasushi Okada, Tomohiro Shima, Mika Tsujii, Katsumi Imada, Taro Ichimura, Tomonobu M. Watanabe
Biophysics and Physicobiology, Vol. 16, pp. 147-157(2019)


 Second-harmonic generation (SHF) microscopy is an imaging method based on nonlinear optical process without needs for labelling specimens. SHF microscopy methods bring structural and chemical information of materials, and thus, this method is expected to be applicable for analysis of conformational dynamics of biomolecules. However, due to the difficulties of optical system setup as well as data analysis, the application of SHF microscopy for biomaterials has been very limited. Particularly, analysis of the conformational dynamics of biomolecules and/or molecular assembly was rarely reported. In the present paper, the authors reported a method for structural analysis of biomolecules, based on the SHG polarizing measurement. The authors successfully measured the conformational changes of microtubule upon chemical stimulus as well as the structural change of a photoswitchable protein upon the irradiation of activation light. Thus, the authors established SHG-based label-free imaging method for structural analysis in real-time that would unveil molecular dynamics of biomolecular systems that have not been accessible with conventional imaging or structural analysis methods.

“Food deprivation changes chemotaxis behavior in Caenorhabditis elegans
Kei Shimizu, Keita Ashida, Kohji Hotta, Kotaro Oka
Biophysics and Physicobiology, Vol. 16, pp. 167-172(2020)


 The state of food deprivation affects the behavior of animals. Chemotaxis is important in the behavior for food searching in C. elegans. In the present study, the authors showed the relationship between the food deprivation and the chemotactic strategy. The short-term food deprivation caused the weathervane strategy, whereas the long-term food deprivation gave the pirouette strategy. Thus, this study clearly showed that the worms change the chemotactic strategy in a different way depending on the period of food deprivation. The Editor-in-Charge thinks that these results give us a model answer for animal behaviors, further paving the new way for the neural network in a food-searching behavior.

“Snake Cube Puzzle and Protein Folding”
Nobuhiro Go
Biophysics and Physicobiology, Vol. 16, pp. 256-263(2019)


 This paper is very impressive and interesting to learn theoretical aspect of protein folding, and is attractive to not only specialists but also beginners. This is "the biophysics".

“Bohr equation and the lost allosteric Bohr effects in Symmetry”
Lihsin Lee
Biophysics and Physicobiology, Vol. 16, pp. 490-503(2019)


 The author is an independent physician of anesthesia. He questioned the Monod-Wyman-Changeux (MWC) theory from a physiological point of view. He revealed that the mathematical need of a fictional monomer by MWC model justified a symmetric logistic curve with a parabolic kernel of dissociation constant to model the sigmoid curves published in 1904 by Bohr et al. He claimed that the logistic-derived Bohr equation and its half-saturated P50 equation could explain the 1904 sigmoidal curves. The Bohr equation suggested that nature should have chosen the allosteric Bohr effects to modify hemoglobin to cope with the swift dynamic of gas exchange. His method in analysis is highly original as well as the unique conclusion. This contribution would provide a new insight into the allosteric Bohr effects in hemoglobin.

Biophysics and Physicobiology編集委員会