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「Biophysics and Physicobiology」に Maki Kawasaki, Masayuki Oda による "DNA-binding function of c-Myb R2R3 around thermal denaturation temperature" を掲載

2021年04月13日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Maki Kawasaki, Masayuki Oda
"DNA-binding function of c-Myb R2R3 around thermal denaturation temperature"

【Significance】
To evaluate the protein fluctuation of c-Myb R2R3, we analyzed its DNA-binding thermodynamics and folding thermodynamics. DNA-binding analysis revealed that the heat capacity change became highly negative above 35°C, indicating that the fluctuation increases with increasing temperature and elevates the conformational change on DNA binding. The results were in accordance with those of folding thermodynamics of R2R3 in the absence or presence of DNA. It should also be noted that R2R3 could specifically bind to DNA around the thermal denaturation temperature. This would be due to the property of protein with large fluctuation.

Biophysics Physicobiology, 2021, Volume 18, Pages 78-84


URL:https://doi.org/10.2142/biophysico.bppb-v18.009


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