ニュース

「Biophysics and Physicobiology」に Katsumi Omagari, Kaori Asamitsu, Yasuhito Tanaka による "Application of fluorescent-based technology detecting protein-protein interactions to monitor the binding of hepatitis B virus X protein to DNA-damage-binding protein 1" を掲載

2021年04月13日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Katsumi Omagari, Kaori Asamitsu, Yasuhito Tanaka
"Application of fluorescent-based technology detecting protein-protein interactions to monitor the binding of hepatitis B virus X protein to DNA-damage-binding protein 1"

【Significance】
The hepatitis B virus X protein (HBx) binds DDB1 to activate viral amplification and is expected to be the target of new viral inhibitors. Although DDB1 binds to several cellular substrates and some viral proteins, with diverse amino acid sequences, it remains to be determined how it recognizes DDB1. The Fluoppi system shows that binding of HBx to DDB1 interferes with the binding of DCAF9 to DDB1. The Fluoppi system is also useful for monitoring the effects of drugs inhibiting HBx-binding. Our results indicate that the Fluoppi system provides the insights into the mechanism through which substrates and drugs interact with DDB1 in cells.

Biophysics Physicobiology, 2021, Volume 18, Pages 67-77


URL:https://doi.org/10.2142/biophysico.bppb-v18.008


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