ニュース

「Biophysics and Physicobiology」に Ryota Kojima, Takashi Yoshidome による "A measure for the identification of preferred particle orientations in cryo-electron microscopy data: A simulation study" を掲載

2021年05月13日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Ryota Kojima, Takashi Yoshidome
"A measure for the identification of preferred particle orientations in cryo-electron microscopy data: A simulation study"

【Significance】
Cryo-electron microscopy (cryo-EM) enables to reconstruct the three-dimensional electron density map of a biomolecule using two-dimensional electron-density maps, experimentally sampled via electron beam irradiation of vitreous ice in which the biomolecules were embedded. However, preferred biomolecular orientations in the vitreous ice often hamper the reconstruction. Thus, it is necessary to identify whether cryo-EM data is obtained from the biomolecules adopting a preferred orientation. Here we propose a measure for the identification based on the manifold learning. It is found that our measure can certainly identify that the biomolecules adopt preferred orientations, suggesting a usefulness of the measure.

Biophysics Physicobiology, 2021, Volume 18, Pages 96-107



URL:https://doi.org/10.2142/biophysico.bppb-v18.011


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