2012年08月03日 会合
主催:よこはまNMR構造生物学研究会
日時:2012年10月11日(木)、12日(金)
場所:理化学研究所・横浜研究所交流棟ホール
(神奈川県横浜市鶴見区 JR鶴見駅東口より臨港バス「ふれーゆ行」で理研市大大学
院前下車)
参加費:
正会員無料/非会員5,000円(事前登録要)詳しくはお問合せください。
懇親会:
2012年10月11日(予定) 会費5,000円(事前登録要)詳しくはお問合せください。
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[プログラム]
【第1日:2012年10月11日(木)】
10:00-10:10 Introduction :Yoshifumi Nishimura (Yokohama City Univ.)
10:10-11:00 Peter Wright (Scripps, USA)
The evolution of protein dynamics
11:00-11:30 Yoshifumi Nishimura (Yokohama City Univ., Japan)
Dynamics of nuclear proteins
11:30-12:00 Takanori Kigawa (RIKEN, Japan)
Stable isotope labeling using cell-free protein synthesis for drug discovery
and design by NMR
12:00-12:30 Chojiro Kojima (Osaka Univ., Japan)
New sensitivity-enhancement methods for ultra-high field solution NMR
12:30-13:30 Lunch
13:30-14:00 Ichio Shimada (Univ. Tokyo, Japan)
Functional analyses of membrane proteins by NMR
14:00-14:30 Mizuki Takahashi (Daiichi-Sankyo, Japan)
Stabilization and refolding of membrane proteins using a flexible tethering
method
14:30-15:00 Takeshi Murata (Chiba Univ. Japan)
Molecular basis of G-protein coupled receptor inactivation by an allosteric
inverse-agonist antibody
15:00-15:50 Sang Ho Park (UCSD, USA)
NMR Structure of the Chemokine Receptor CXCR1 and Interactions with Its
Ligands
15:50-16:10 Intermission
16:10-17:00 Wolfgang Jahnke (Novartis, Switzerland)
NMR in lead discovery and optimization
17:30-19:30 Banquet
【第2日:2012年10月12日(金)】
9:50-10:40 Mitsuhiko Ikura (Univ. Toronto, Canada)
A Role of NMR in the "Personalized Medicine" Era
10:40-11:10 Kiyoshi Fukuhara (NIHS, Japan)
The application of NMR-based metabolomics in drug development
11:10-11:40 Toshiya Senda (BIRC, Japan)
Tertiary structure and functional analysis of the Helicobacter pylori CagA
oncoprotein
11:40-12:30 Bong-Jin Lee (Seoul National Univ., Korea)
Structural analysis of hypothetical proteins from Helicobacter pylori for new
antibiotic target :
an approach to estimate functions of unknown or hypothetical proteins
12:30-13:30 Lunch
13:30-14:00 Akinori Kidera (Yokohama City Univ., Japan)
Simulation and database studies on protein structural changes upon ligand
binding
14:00-14:30 Atsuko Yamashita (Okayama Univ. Japan)
Structural basis of dynamic regulation of ion channel function
14:30-15:00 Midori Takimoto-Kamimura (Teijin, Japan)
The structure basis of C-terminal domain secretory leukocyte protease
inhibitor and its function
15:00-15:30 Kazutaka Shinbo (Ajinomoto Co., Japan)
Quantitative Profiling of Caspase Cleaved Substrates in Apoptosis
15:30-15:50 Intermission
15:50-16:20 Hideo Takahashi (Yokohama City Univ., Japan)
NMR approach for ligand-based drug discovery
16:20-17:10 Gerhard Wagner (Harvard, USA)
Inhibiting protein-protein interactions for cancer therapy
17:10-17:20 Closing :Yoshifumi Nishimura
連絡先:
よこはまNMR構造生物学研究会事務局
〒230-0045横浜市鶴見区末広町1-7-29
横浜市立大学大学院生命ナノシステム科学研究科 西村善文
TEL:045-508-7530 FAX:045-508-7362
URL: http://www.tsurumi.yokohama-cu.ac.jp/ynmr/