ニュース

「Biophysics and Physicobiology」に Ryo Iizuka et al.“Chaperonin GroEL uses asymmetric and symmetric reaction cycles in response to the concentration of non-native substrate proteins”を掲載

2016年04月25日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Ryo Iizuka and Takashi Funatsu
“Chaperonin GroEL uses asymmetric and symmetric reaction cycles in response to the concentration of non-native substrate proteins”

【Significance】
GroEL uses two types of reaction cycles in response to the concentration of non-native proteins

The chaperonin GroEL is a double-ring structure that assists protein folding in association with its cofactor GroES. It is widely accepted that an asymmetric GroEL−GroES complex is formed throughout the reaction cycle, whereas a symmetric GroEL−(GroES)2 complex is not formed. However, this conventional view has been challenged by the recent reports indicating that such symmetric complexes can be formed in the reaction cycle. We suggest that GroEL uses two types of reaction cycles (asymmetric or symmetric) in response to the concentration of non-native proteins.


Biophysics and Physicobiology, Vol.13, pp. 63-69

URL:https://www.jstage.jst.go.jp/article/biophysico/13/0/13_63/_article



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