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「Biophysics and Physicobiology」に Koya Sakuma による "Limitations of the ABEGO-based backbone design: ambiguity between αα-corner and αα-hairpin" を掲載

2021年06月18日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Koya Sakuma
"Limitations of the ABEGO-based backbone design: ambiguity between αα-corner and αα-hairpin"

【Significance】
ABEGO is a coarse-grained representation for polypeptide backbone dihedral angles. I show ABEGO representation is unable to distinguish certain type of helix-loop-helix fragments, which causes the loss of efficiency in the fragment-assembly simulations for construction of backbone model in de novo protein design. Understanding the limitation of commonly used coarse-grained representations is important for improvement of backbone-building strategies in de novo protein design.

Biophysics Physicobiology, 2021, Volume 18, Pages 159-167



URL:https://doi.org/10.2142/biophysico.bppb-v18.017


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