ニュース

「Biophysics and Physicobiology」に Izuru Kawamura, Hayato Seki, Seiya Tajima, Yoshiteru Makino, Arisu Shigeta, Takashi Okitsu, Akimori Wada, Akira Naito, Yuki Sudo による "Structure of a retinal chromophore of dark-adapted middle rhodopsin as studied by solid-state nuclear magnetic resonance spectroscopy" を掲載

2021年08月07日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Izuru Kawamura, Hayato Seki, Seiya Tajima, Yoshiteru Makino, Arisu Shigeta, Takashi Okitsu, Akimori Wada, Akira Naito, Yuki Sudo
"Structure of a retinal chromophore of dark-adapted middle rhodopsin as studied by solid-state nuclear magnetic resonance spectroscopy"

【Significance】
Here, we analyzed the structure of the retinal chromophore of middle rhodopsin (MR) embedded in lipid bilayers using solid-state NMR spectroscopy. We recorded the 13C NMR signals of three types of retinal configurations of dark-adapted MR exist: (13-trans, 15-anti), (13-cis, 15-syn), and 11-cis isomers. Furthermore, we discretely observed 13Cζ NMR signals of Tyr185 in MR with the all-trans and 13-cis isomers. The 15N NMR signal of the protonated Schiff base in MR exhibited a strong electrostatic interaction with the counter ion. Our study makes a significant contribution to the literature because we highlighted the key structural chromophores of MR.

Biophysics Physicobiology, 2021, Volume 18, Pages 177-185



URL:https://doi.org/10.2142/biophysico.bppb-v18.019


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